Ontology highlight
ABSTRACT:
SUBMITTER: Heim VJ
PROVIDER: S-EPMC7645253 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Heim Valentin J VJ Dagley Laura F LF Stafford Che A CA Hansen Fynn M FM Clayer Elise E Bankovacki Aleksandra A Webb Andrew I AI Lucet Isabelle S IS Silke John J Nachbur Ueli U
EMBO reports 20200921 11
Signaling via the intracellular pathogen receptors nucleotide-binding oligomerization domain-containing proteins NOD1 and NOD2 requires receptor interacting kinase 2 (RIPK2), an adaptor kinase that can be targeted for the treatment of various inflammatory diseases. However, the molecular mechanisms of how RIPK2 contributes to NOD signaling are not completely understood. We generated FLAG-tagged RIPK2 knock-in mice using CRISPR/Cas9 technology to study NOD signaling mechanisms at the endogenous l ...[more]