Evidence for a non-stochastic two-field hypothesis for persistent skin cancer risk.

ABSTRACT: With recurring carcinogen exposures, individual tumors develop in a field of genetic mutations through a stepwise process of clonal expansion and evolution. Once established, this "cancer field" persists in the absence of continued carcinogen exposures, resulting in a sustained risk for cancer development. Using a bioimaging approach, we previously demonstrated that a dermal premalignant field characterized by inflammatory angiogenesis persists following the cessation of ultraviolet light exposures and accurately predicts future overlying epidermal tumor formation. Following ultraviolet light treatments, others have observed that patches of p53 immunopositive cells persist stochastically throughout the epidermal stem cell population. However, these studies were done by random biopsies, int

SUBMITTER: Konger RL 

PROVIDER: S-EPMC7645611 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature