Ontology highlight
ABSTRACT:
SUBMITTER: Petrova V
PROVIDER: S-EPMC7645621 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Nature communications 20201105 1
Adult mammalian central nervous system axons have intrinsically poor regenerative capacity, so axonal injury has permanent consequences. One approach to enhancing regeneration is to increase the axonal supply of growth molecules and organelles. We achieved this by expressing the adaptor molecule Protrudin which is normally found at low levels in non-regenerative neurons. Elevated Protrudin expression enabled robust central nervous system regeneration both in vitro in primary cortical neurons and ...[more]