Characterization and stabilization in process development and product formulation for super large proteinaceous particles.

ABSTRACT: Super large proteinaceous particles (SLPPs) such as virus, virus like particles, and extracellular vesicles have successful and promising applications in vaccination, gene therapy, and cancer treatment. The unstable nature, the complex particulate structure and composition are challenges for their manufacturing and applications. Rational design of the processing should be built on the basis of fully understanding the characteristics of these bio-particles. This review highlights useful analytical techniques for characterization and stabilization of SLPPs in the process development and product formulations, including high performance size exclusion chromatography, multi-angle laser light scattering, asymmetrical flow field-flow fractionation, nanoparticle tracking analysis, CZE, differentia

SUBMITTER: Yang Y 

PROVIDER: S-EPMC7645648 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature