Trends in Positive BRCA Test Results Among Older Women in the United States, 2008-2018.

ABSTRACT:

Importance

Genetic testing for BRCA1/2 pathogenic variants has been used for targeted, individualized cancer prevention and treatment. A positive BRCA test result indicates a higher risk for developing BRCA-related cancers. During the past decade, testing criteria have loosened. The impact of these loosened criteria on BRCA testing in older women has not previously been studied.

Objective

To assess whether the rate of positive BRCA test results changed between 2008 and 2018 among older women in the United States.

Design, setting, and participants

This cross-sectional study used a 10% random sample of women 65 years of age or older from Optum's deidentified Integrated Claims-Clinical data set (2008-2018), a large national electronic health record data set. A total of 5

SUBMITTER: Guo F 

PROVIDER: S-EPMC7645697 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature