Association of Serum Neurofilament Light Levels With Long-term Brain Atrophy in Patients With a First Multiple Sclerosis Episode.

ABSTRACT:

Importance

Data are needed on the potential long-term prognostic association of serum neurofilament light in multiple sclerosis (MS).

Objective

To evaluate serum neurofilament light as a biomarker associated with long-term disease outcomes in clinically isolated syndrome.

Design, setting, and participants

This post hoc cohort study used data from the Controlled High-Risk Avonex Multiple Sclerosis Prevention Study, a 36-month, multicenter, placebo-controlled interferon β-1a randomized clinical trial conducted from April 1996 to March 2000, and its long-term (5- and 10-year) extension study from February 2001 to March 2009. Participants included individuals with a symptomatic initial demyelinating event and brain magnetic resonance imaging (MRI) lesions suggestive of MS

SUBMITTER: Plavina T 

PROVIDER: S-EPMC7645699 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature