Single-cell analysis identified lung progenitor cells in COVID-19 patients.

ABSTRACT:

Objectives

The high mortality of severe 2019 novel coronavirus disease (COVID-19) cases is mainly caused by acute respiratory distress syndrome (ARDS), which is characterized by increased permeability of the alveolar epithelial barriers, pulmonary oedema and consequently inflammatory tissue damage. Some but not all patients showed full functional recovery after the devastating lung damage, and so far there is little knowledge about the lung repair process. We focused on crucial roles of lung progenitor cells in alveolar cell regeneration and epithelial barrier re-establishment and aimed to uncover a possible mechanism of lung repair after severe SARS-CoV-2 infection.

Materials and methods

Bronchoalveolar lavage fluid (BALF) of COVID-19 patients was analysed by single-cell RN

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC7645905 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature