Spontaneous regression of micro-metastases following primary tumor excision: a critical role for primary tumor secretome.

ABSTRACT:

Background

Numerous case studies have reported spontaneous regression of recognized metastases following primary tumor excision, but underlying mechanisms are elusive. Here, we present a model of regression and latency of metastases following primary tumor excision and identify potential underlying mechanisms.

Results

Using MDA-MB-231^HM human breast cancer cells that express highly sensitive luciferase, we monitored early development stages of spontaneous metastases in BALB/c nu/nu mice. Removal of the primary tumor caused marked regression of micro-metastases, but not of larger metastases, and in vivo supplementation of tumor secretome diminished this regression, suggesting that primary tumor-secreted factors promote early metastatic growth. Correspondingly, MDA-

SUBMITTER: Shaashua L 

PROVIDER: S-EPMC7646068 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature