Current Understanding of Immunity Against Schistosomiasis: Impact on Vaccine and Drug Development.

ABSTRACT: Schistosomiasis is a neglected tropical disease inflicting significant morbidity in humans worldwide. The disease is caused by infections with a parasitic trematode belonging to the genus Schistosoma. Over 250 million people are currently infected globally, with an estimated disability-adjusted life-years of 1.9 million attributed to the disease. Current understanding, based on several immunological studies using experimental and human models of schistosomiasis, reveals that complex immune mechanisms play off each other in the acquisition of immune resistance to infection/reinfection. Nevertheless, the precise characteristics of these responses, the specific antigens against which they are elicited, and how these responses are intricately regulated are still being investigated. What

SUBMITTER: Molehin AJ 

PROVIDER: S-EPMC7646453 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature