Targeting IL-27 and/or IL-10 in Experimental Murine Visceral Leishmaniasis.

ABSTRACT: Interleukin-10 (IL-10) and interleukin-27 (IL-27) both exert counterregulatory immunodeactivation in visceral Leishmania donovani infection. We studied experimental L. donovani infection in the livers of IL-10^-/- and IL-27Rα^-/- mice and observed that in IL-27Rα^-/-, but not IL-10^-/- mice, interferon-gamma (IFN-γ) and tumor necrosis factor (TNF) were required for heightened granulomatous inflammation and accelerated control of intracellular parasite replication. This difference in mechanism, along with residual IL-10 activity in IL-27Rα^-/- mice, suggested targeting IL-27 in addition to IL-10 in a macrophage-activating, anti-counterregulatory cytokine treatment strategy. In C57BL/6 wild-type mice with established liver infec

SUBMITTER: Murray HW 

PROVIDER: S-EPMC7646755 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature