Colonisation with extended spectrum beta-lactamase-producing and carbapenem-resistant Enterobacterales in children admitted to a paediatric referral hospital in South Africa.

ABSTRACT:

Introduction

There are few studies describing colonisation with extended spectrum beta-lactamase-producing Enterobacterales (ESBL-PE) and carbapenem-resistant Enterobacterales (CRE) among children in sub-Saharan Africa. Colonisation often precedes infection and multi-drug-resistant Enterobacterales are important causes of invasive infection.

Methods

In this prospective cross-sectional study, conducted between April and June 2017, 200 children in a tertiary academic hospital were screened by rectal swab for EBSL-PE and CRE. The resistance-conferring genes were identified using polymerase chain reaction technology. Risk factors for colonisation were also evaluated.

Results

Overall, 48% (96/200) of the children were colonised with at least one ESBL-PE, 8.3% (8/96) of the

SUBMITTER: Ogunbosi BO 

PROVIDER: S-EPMC7647087 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature