Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling.

ABSTRACT: It is of great interest to understand how invading pathogens are sensed within the brain, a tissue with unique challenges to mounting an immune response. The eukaryotic parasite Toxoplasma gondii colonizes the brain of its hosts, and initiates robust immune cell recruitment, but little is known about pattern recognition of T. gondii within brain tissue. The host damage signal IL-33 is one protein that has been implicated in control of chronic T. gondii infection, but, like many other pattern recognition pathways, IL-33 can signal peripherally, and the specific impact of IL-33 signaling within the brain is unclear. Here, we show that IL-33 is expressed by oligodendrocytes and astrocytes during T. gondii infection, is released locally into the cerebrospinal fluid of T. gondii-infected animal

SUBMITTER: Still KM 

PROVIDER: S-EPMC7647122 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature