Maintaining intestinal structural integrity is a potential protective mechanism against inflammation in goose fatty liver.

ABSTRACT: Overfeeding causes severe steatosis but not inflammation in goose liver, suggesting existence of protective components. Previous studies have shown that some intestinal microbes and their metabolites damage intestinal structural integrity and function, thus causing inflammation in the development of human and mouse nonalcoholic fatty liver disease. Therefore, this study hypothesizes that intestinal structural integrity of goose is maintained during overfeeding, which may provide goose fatty liver a protective mechanism against inflammation. To test this hypothesis, 48 seventy-day-old healthy Landes male geese were overfed (as overfeeding group) or normally fed (as control group). Blood and intestine (jejunum, ileum, and cecum) samples were harvested on the 12^th and 24^th

SUBMITTER: Gu W 

PROVIDER: S-EPMC7647926 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature