The Effects of an Albumin Binding Moiety on the Targeting and Pharmacokinetics of an Integrin α_vβ₆-Selective Peptide Labeled with Aluminum [¹⁸F]Fluoride.

ABSTRACT:

Purpose

The α_vβ₆-BP peptide selectively targets the integrin α_vβ₆, a cell surface receptor recognized as a prognostic indicator for several challenging malignancies. Given that the 4-[¹⁸F]fluorobenzoyl (FBA)-labeled peptide is a promising PET imaging agent, radiolabeling via aluminum [¹⁸F]fluoride chelation and introduction of an albumin binding moiety (ABM) have the potential to considerably simplify radiochemistry and improve the pharmacokinetics by increasing biological half-life.

Procedures

The peptides NOTA-α_vβ₆-BP (1) and NOTA-K(ABM)-α_vβ₆-BP (2) were synthesized on solid phase, radiolabeled with aluminum [¹⁸F]fluoride, and evaluated in vitro (integri

SUBMITTER: Hausner SH 

PROVIDER: S-EPMC7647958 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature