Verbal memory and hippocampal volume predict subsequent fornix microstructure in those at risk for Alzheimer's disease.

ABSTRACT: While strong cross-sectional evidence supported the use of fornix microstructure as a marker for detecting Alzheimer's disease (AD), longitudinal data remains inconclusive on the sequential nature of fornix microstructure abnormalities and AD progression. An unequivocal longitudinal relationship between fornix microstructure and markers of AD progression -memory impairment and hippocampal atrophy, must be established to validate fornix microstructure as a marker of AD progression. We included 115 participants from the Alzheimer's Disease Neuroimaging Initiative across the non-demented AD spectrum- defined as those who had at least one AD risk marker at baseline (e.g., mild cognitive impairment (MCI) due to AD diagnosis, amyloid or ApoE4 positivity) and/or 'cognitively normal individuals wh

SUBMITTER: Yu J 

PROVIDER: S-EPMC7647989 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature