Differential insular cortex sub-regional atrophy in neurodegenerative diseases: a systematic review and meta-analysis.

ABSTRACT: The insular cortex is proposed to function as a central brain hub characterized by wide-spread connections and diverse functional roles. As a result, its centrality in the brain confers high metabolic demands predisposing it to dysfunction in disease. However, the functional profile and vulnerability to degeneration varies across the insular sub-regions. The aim of this systematic review and meta-analysis is to summarize and quantitatively analyze the relationship between insular cortex sub-regional atrophy, studied by voxel based morphometry, with cognitive and neuropsychiatric deficits in frontotemporal dementia (FTD), Alzheimer's disease (AD), Parkinson's disease (PD), and dementia with Lewy bodies (DLB). We systematically searched through Pubmed and Embase and identified 519 studies th

SUBMITTER: Fathy YY 

PROVIDER: S-EPMC7648006 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature