Oroxylin A alleviates immunoparalysis of CLP mice by degrading CHOP through interacting with FBXO15.

ABSTRACT: Clinical reports have found that with the improvement of treatment, most septic patients are able to survive the severe systemic inflammatory response and to enter the immunoparalysis stage. Considering that immunoparalysis leads to numerous deaths of clinical sepsis patients, alleviation of the occurrence and development of immunoparalysis has become a top priority in the treatment of sepsis. In our study, we investigate the effects of oroxylin A on sepsis in cecal ligation and puncture (CLP) mice. We find that the 60 h + 84 h (30 mg/kg) injection scheme of oroxylin A induce the production of pro-inflammatory factors, and further significantly improves the survival of CLP mice during the middle or late stages of sepsis. Mechanistically, C/EBP-homologous protein (CHOP) is upregulated and p

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC7648083 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature