Photobiomodulation drives pericyte mobilization towards skin regeneration.

ABSTRACT: Photobiomodulation is being widely applied for improving dermal or mucosal wound healing. However, the underlying cellular and molecular processes that directly contribute to its effects remain poorly understood. Pericytes are relevant cells involved in the wound microenvironment and could be one of the main targets of photobiomodulation due to their plasticity and perivascular localization. Herein, we investigate tissue repair under the photobiomodulation stimulus using a pericyte labeled (or reporter) transgenic mice. Using a model of two contralateral back wounds, one the control and the other photoactivated daily (660 nm, 20 mW, 0.71 W/cm², 5 J/cm², 7 s, 0.14 J), we showed an overall influx of immune and undifferentiated cells and higher mobilization of a potent p

SUBMITTER: do Valle IB 

PROVIDER: S-EPMC7648092 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature