A prognostic gene expression signature for oropharyngeal squamous cell carcinoma.

ABSTRACT:

Background

Robust prognostic stratification of patients with oropharyngeal squamous cell carcinoma (OPSCC) is important for developing individualized treatment plans. This study was conducted to develop and validate a clinically feasible prognostic classifier based on transcriptome-wide gene expression profiles.

Methods

Tumor tissues were collected from 208 OPSCC patients treated at Washington University in St. Louis and 130 OPSCC patients treated at Vanderbilt University, used for model training and validation, respectively. OPSCC patients (n = 70) from the TCGA cohort were also included for independent validation. Based on RNA-seq profiling data, Cox proportional hazards regression analysis was performed to identify genes associated with disease outcomes. Then, Lasso-penal

SUBMITTER: Liu X 

PROVIDER: S-EPMC7648117 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature