Sleep Disturbance during Infection Compromises Tfh Differentiation and Impacts Host Immunity.

ABSTRACT: Although the influence of sleep quality on the immune system is well documented, the mechanisms behind its impact on natural host immunity remain unclear. Meanwhile, it has been suggested that neuroimmune interactions play an important role in this phenomenon. To evaluate the impact of stress-induced sleep disturbance on host immunity, we used a murine model of rapid eye movement sleep deprivation (RSD) integrated with a model of malaria blood-stage infection. We demonstrate that sleep disturbance compromises the differentiation of T follicular helper cells, increasing host susceptibility to the parasite. Chemical inhibition of glucocorticoid (Glcs) synthesis showed that abnormal Glcs production compromised the transcription of Tfh-associated genes resulting in impaired germinal center for

SUBMITTER: Fernandes ER 

PROVIDER: S-EPMC7648138 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature