Disruption of VirB6 Paralogs in Anaplasma phagocytophilum Attenuates Its Growth.

ABSTRACT: Many pathogenic bacteria translocate virulence factors into their eukaryotic hosts by means of type IV secretion systems (T4SS) spanning the inner and outer membranes. Genes encoding components of these systems have been identified within the order Rickettsiales based upon their sequence similarities to other prototypical systems. Anaplasma phagocytophilum strains are obligate intracellular, tick-borne bacteria that are members of this order. The organization of these components at the genomic level was determined in several Anaplasma phagocytophilum strains, showing overall conservation, with the exceptions of the virB2 and virB6 genes. The virB6 loci are characterized by the presence of four virB6 copies (virB6-1 through virB6-4<

SUBMITTER: Crosby FL 

PROVIDER: S-EPMC7648143 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature