Identification and Validation of STAT6 as a Prognostic and Predictive Biomarker in Acute Myeloid Leukemia.

ABSTRACT:

Background

Acute myeloid leukemia (AML) is one of the most common hematological diseases in adults. The overall survival rate remains unsatisfactory. It is urgent to identify potential prognostic biomarkers and develop new molecular therapeutic strategies for AML. Signal transducer and activator of transcription (STAT) is a family of genes that encode intracellular transcription factors. STATs are associated with leukemogenesis, cellular transformation, and cell cycle in AML.

Methods

We used sequencing data and clinical data from The Cancer Genome Atlas (TCGA) and ONCOMINE to identify expression difference, gene variability and correlation as well as prognostic effects of STAT genes in AML patients. Then, we verified the expression difference of STAT6 between healthy

SUBMITTER: Liu W 

PROVIDER: S-EPMC7648156 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature