Dynamics of the Stool Virome in Very Early-Onset Inflammatory Bowel Disease.

ABSTRACT:

Background and aims

Dysbiosis of the gut microbiota is a well-known correlate of the pathogenesis of inflammatory bowel disease [IBD]. However, few studies have examined the microbiome in very early-onset [VEO] IBD, which is defined as onset of IBD before 6 years of age. Here we focus on the viral portion of the microbiome-the virome-to assess possible viral associations with disease processes, reasoning that any viruses potentially associated with IBD might grow more robustly in younger subjects, and so be more detectable.

Methods

Virus-like particles [VLPs] were purified from stool samples collected from patients with VEO-IBD [n = 54] and healthy controls [n = 23], and characterized by DNA and RNA sequencing and VLP particle counts.

Results

The total number of VLPs

SUBMITTER: Liang G 

PROVIDER: S-EPMC7648169 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature