Discovery, validation and sequencing of urinary peptides for diagnosis of liver fibrosis-A multicentre study.

ABSTRACT:

Background

Liver fibrosis is a consequence of chronic inflammation and is associated with protein changes within the hepatocytes structure. In this study, we aimed to investigate if this is reflected by the urinary proteome and can be explored to diagnose liver fibrosis in patients with chronic liver disease.

Methods

In a multicentre combined cross-sectional and prospective diagnostic test validation study, 129 patients with varying degrees of liver fibrosis and 223 controls without liver fibrosis were recruited. Additionally, 41 patients with no liver, but kidney fibrosis were included to evaluate interference with expressions of kidney fibrosis. Urinary low molecular weight proteome was analysed by capillary electrophoresis coupled to mass spectrometry (CE-MS) and a suppor

SUBMITTER: Bannaga AS 

PROVIDER: S-EPMC7648178 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature