Microfilaria-dependent thoracic pathology associated with eosinophilic and fibrotic polyps in filaria-infected rodents.

ABSTRACT:

Background

Pulmonary manifestations are regularly reported in both human and animal filariasis. In human filariasis, the main known lung manifestations are the tropical pulmonary eosinophilia syndrome. Its duration and severity are correlated with the presence of microfilariae. Litomosoides sigmodontis is a filarial parasite residing in the pleural cavity of rodents. This model is widely used to understand the immune mechanisms that are established during infection and for the screening of therapeutic molecules. Some pulmonary manifestations during the patent phase of infection with L. sigmodontis have been described in different rodent hosts more or less permissive to infection.

Methods

Here, the permissive Mongolian gerbil (Meriones unguiculatus) was infected with L. sigmo

SUBMITTER: Fercoq F 

PROVIDER: S-EPMC7648300 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature