Leptomeningeal Spread in Glioblastoma: Diagnostic and Therapeutic Challenges.

ABSTRACT:

Background

Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor. Leptomeningeal spread (LMS) is a severe complication of GBM, raising diagnostic and therapeutic challenges in clinical routine.

Methods

We performed a review of the literature focused on LMS in GBM. MEDLINE and EMBASE databases were queried from 1989 to 2019 for articles describing diagnosis and therapeutic options in GBM LMS, as well as risk factors and pathogenic mechanisms.

Results

We retrieved 155 articles, including retrospective series, case reports, and early phase clinical trials, as well as preclinical studies. These articles confirmed that LMS in GBM remains (a) a diagnostic challenge with cytological proof of LMS obtained in only 35% of cases and (b) a therapeutic

SUBMITTER: Birzu C 

PROVIDER: S-EPMC7648332 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature