The Predictive Value of Early Changes in ¹⁸ F-Fluoroestradiol Positron Emission Tomography/Computed Tomography During Fulvestrant 500 mg Therapy in Patients with Estrogen Receptor-Positive Metastatic Breast Cancer.

ABSTRACT:

Background

The aim of this study was to investigate the predictive value of early changes in ¹⁸ F-fluoroestradiol (FES) positron emission tomography (PET)/computed tomography (CT) during fulvestrant 500 mg therapy in patients with estrogen receptor (ER)-positive metastatic breast cancer.

Materials and methods

Patients underwent ¹⁸ F-FES PET/CT scans at both baseline (scan 1) and day 28 (scan 2). The maximum standardized uptake value (SUVmax) of all metastatic sites was determined in each scan, and the percentage reduction in SUVmax (ΔSUVmax) was calculated as [(SUVmax on scan 1-SUVmax on scan 2)/ SUVmax on scan 1] * 100%.

Results

In total, 294 ¹⁸ F-FES-positive lesions from 36 patients were identified. The ¹⁸ F-FES SUVmax va

SUBMITTER: He M 

PROVIDER: S-EPMC7648347 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature