Combined thrombogenic effects of vessel injury, pregnancy and procoagulant immune globulin administration in mice.

ABSTRACT:

Background

Pregnant women are at increased risk of thrombotic adverse events. Plasma derived immune globulin (IG) products, which are used in pregnancy for various indications, may contain procoagulant impurity activated coagulation factor XI (FXIa). Procoagulant IG products have been associated with increased thrombogenicity but their effect in pregnancy is unknown.

Methods

Late pregnant (gestation days 17-20) or early lactation (days 1-3) and control female mice were treated with IGs supplemented with human FXIa then subjected to ferric chloride (FeCl₃) vessel injury. Occlusion of blood vessel was assessed by recording blood velocity in the femoral vein for 20 min using doppler ultrasound laser imaging. FXIa dose was selected by the ability to increase thrombin

SUBMITTER: Xu Y 

PROVIDER: S-EPMC7648396 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature