Expanded circulating follicular dendritic cells facilitate immune responses in chronic HBV infection.

ABSTRACT:

Background

The restoration of host hepatitis B virus (HBV)-specific antiviral immunity is an effective strategy for hepatitis B recovery. Follicular dendritic cells (FDCs) play a crucial role in immune regulation. The goal of the present study was to investigate the characteristics and functions of FDCs in chronic HBV infection.

Methods

The frequencies of FDCs in peripheral blood, liver, and spleen were measured in patients with chronic HBV infection. Isolated FDCs from splenic tissues of HBV-related liver cirrhosis-induced hypersplenism patients were cultured with autologous intrasplenic CD4⁺ T cells and CD19⁺ B cells.

Results

We observed that patients with chronic HBV infection had a significantly increased frequency of circulating FDCs compare

SUBMITTER: Li X 

PROVIDER: S-EPMC7648402 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature