Genetic Basis of Aerobically Supported Voluntary Exercise: Results from a Selection Experiment with House Mice.

ABSTRACT: The biological basis of exercise behavior is increasingly relevant for maintaining healthy lifestyles. Various quantitative genetic studies and selection experiments have conclusively demonstrated substantial heritability for exercise behavior in both humans and laboratory rodents. In the "High Runner" selection experiment, four replicate lines of Mus domesticus were bred for high voluntary wheel running (HR), along with four nonselected control (C) lines. After 61 generations, the genomes of 79 mice (9-10 from each line) were fully sequenced and single nucleotide polymorphisms (SNPs) were identified. We used nested ANOVA with MIVQUE estimation and other approaches to compare allele frequencies between the HR and C lines for both SNPs and haplotypes. Approximately 61 genomic regions

SUBMITTER: Hillis DA 

PROVIDER: S-EPMC7648575 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature