Sleep Architecture in Mice Is Shaped by the Transcription Factor AP-2β.

ABSTRACT: The molecular mechanism regulating sleep largely remains to be elucidated. In humans, families that carry mutations in TFAP2B, which encodes the transcription factor AP-2β, self-reported sleep abnormalities such as short-sleep and parasomnia. Notably, AP-2 transcription factors play essential roles in sleep regulation in the nematode Caenorhabditis elegans and the fruit fly Drosophila melanogaster Thus, AP-2 transcription factors might have a conserved role in sleep regulation across the animal phyla. However, direct evidence supporting the involvement of TFAP2B in mammalian sleep was lacking. In this study, by using the CRISPR/Cas9 technology, we generated two Tfap2b mutant mouse strains, Tfap2b^K144 and Tfap2b^K145 , each harb

SUBMITTER: Nakai A 

PROVIDER: S-EPMC7648583 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature