Evidence in cortical folding patterns for prenatal predispositions to hallucinations in schizophrenia.

ABSTRACT: All perception is a construction of the brain from sensory input. Our first perceptions begin during gestation, making fetal brain development fundamental to how we experience a diverse world. Hallucinations are percepts without origin in physical reality that occur in health and disease. Despite longstanding research on the brain structures supporting hallucinations and on perinatal contributions to the pathophysiology of schizophrenia, what links these two distinct lines of research remains unclear. Sulcal patterns derived from structural magnetic resonance (MR) images can provide a proxy in adulthood for early brain development. We studied two independent datasets of patients with schizophrenia who underwent clinical assessment and 3T MR imaging from the United Kingdom and Shanghai, Chi

SUBMITTER: Rollins CPE 

PROVIDER: S-EPMC7648757 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature