Bacterial diets differentially alter lifespan and healthspan trajectories in C. elegans.

ABSTRACT: Diet is one of the more variable aspects in life due to the variety of options that organisms are exposed to in their natural habitats. In the laboratory, C. elegans are raised on bacterial monocultures, traditionally the E. coli B strain OP50, and spontaneously occurring microbial contaminants are removed to limit experimental variability because diet-including the presence of contaminants-can exert a potent influence over animal physiology. In order to diversify the menu available to culture C. elegans in the lab, we have isolated and cultured three such microbes: Methylobacterium, Xanthomonas, and Sphingomonas. The nutritional composition of these bacterial foods is unique, and when fed to C. elegans, can differentially alter multiple life history traits including development, reproduct

SUBMITTER: Stuhr NL 

PROVIDER: S-EPMC7648844 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature