LINC00174 is a novel prognostic factor in thymic epithelial tumors involved in cell migration and lipid metabolism.

ABSTRACT: Long non-coding RNAs are emerging as new molecular players involved in many biological processes, such as proliferation, apoptosis, cell cycle, migration, and differentiation. Their aberrant expression has been reported in variety of diseases. The aim of this study is the identification and functional characterization of clinically relevant lncRNAs responsible for the inhibition of miR-145-5p, a key tumor suppressor in thymic epithelial tumors (TETs). Starting from gene expression analysis by microarray in a cohort of fresh frozen thymic tumors and normal tissues, we identified LINC00174 as upregulated in TET. Interestingly, LINC00174 expression is positively correlated with a 5-genes signature in TETs. Survival analyses, performed on the TCGA dataset, showed that LINC00174 and its associa

SUBMITTER: Tito C 

PROVIDER: S-EPMC7648846 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature