Donor-derived vancomycin-resistant enterococci transmission and bloodstream infection after intestinal transplantation.

ABSTRACT:

Background

Transplant recipients are at high risk for infections. However, donor-recipient transmission of multidrug-resistant organisms (MDROs) remains mostly unaddressed in the protocols of pre-transplant infection and colonization screening. Vancomycin-resistant enterococci (VRE) are MDROs that colonize the gastrointestinal tract and are associated with a significant burden of disease. Besides the high mortality of invasive VRE infections, chronic colonization leads to costly isolation measures in the hospital setting. Whereas most post-transplantation VRE infections are endogenous and thus preceded by colonization of the recipient, conclusive evidence of VRE transmission via allograft in the context of intestinal transplantation is lacking.

Case presentation

We describe

SUBMITTER: Correa-Martinez CL 

PROVIDER: S-EPMC7648953 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature