Transcriptome analysis identifies putative multi-gene signature distinguishing benign and malignant pancreatic head mass.

ABSTRACT:

Background

Most often, the patients with pancreatic diseases are presented with a mass in pancreatic head region and existing methods of diagnosis fail to confirm whether the head mass is malignant or benign. As subsequent management of the disease hugely depends on the correct diagnosis, we wanted to explore possible biomarkers which could distinguish benign and malignant pancreatic head masses.

Methods

In order to address that gap, we performed a case-control study to identify genome-wide differentially expressed coding and noncoding genes between pancreatic tissues collected from benign and malignant head masses. These genes were next shortlisted using stringent criteria followed by selection of top malignancy specific genes. They subsequently got validated by quantitativ

SUBMITTER: Chhatriya B 

PROVIDER: S-EPMC7648960 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature