Association of abnormal placental perfusion with the risk of male hypospadias: a hospital-based retrospective cohort study.

ABSTRACT:

Background

The effect and extent of abnormal placental perfusion (APP) on the risk of male hypospadias are poorly understood. We compared the prevalence of male hypospadias in the offspring of women with APP and quantify the extent of the APP effect on the anomaly.

Methods

A hospital-based retrospective analysis of births from 2012 to 2016 was conducted in 2018. Women of singleton pregnancy and male infants born to them were included (N = 21,447). A multivariate analysis was performed to compare the prevalence of male hypospadias in infants exposed to APP with those that were not exposed to APP.

Results

Compared with the infants of women without APP, infants of women with APP showed an increased risk of male hypospadias (odds ratio, 2.40; 95% confidence interval, 1.09

SUBMITTER: Zhu C 

PROVIDER: S-EPMC7649004 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature