Impaired Hand Dexterity Function in a Non-human Primate Model with Chronic Parkinson's Disease.

ABSTRACT: Symptoms of Parkinson's disease (PD) caused by loss of dopaminergic neurons are accompanied by movement disorders, including tremors, rigidity, bradykinesia, and akinesia. Non-human primate (NHP) models with PD play an essential role in the analysis of PD pathophysiology and behavior symptoms. As impairments of hand dexterity function can affect activities of daily living in patients with PD, research on hand dexterity function in NHP models with chronic PD is essential. Traditional rating scales previously used in the evaluation of animal spontaneous behavior were insufficient due to factors related to subjectivity and passivity. Thus, experimentally designed applications for an appropriate apparatus are necessary. In this study, we aimed to longitudinally assess hand dexterity function u

SUBMITTER: Seo J 

PROVIDER: S-EPMC7649085 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature