Efficient Plant Production of Recombinant NS1 Protein for Diagnosis of Dengue.

ABSTRACT: Dengue fever is endemic in more than 120 countries, which account for 3.9 billion people at risk of infection worldwide. The absence of a vaccine with effective protection against the four serotypes of this virus makes differential molecular diagnosis the key step for the correct treatment of the disease. Rapid and efficient diagnosis prevents progression to a more severe stage of this disease. Currently, the limiting factor in the manufacture of dengue (DENV) diagnostic kits is the lack of large-scale production of the non-structural 1 (NS1) protein (antigen) to be used in the capture of antibodies from the blood serum of infected patients. In this work, we use plant biotechnology and genetic engineering as tools for the study of protein production for research and commercial purposes. Ge

SUBMITTER: Xisto MF 

PROVIDER: S-EPMC7649140 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature