Fine Particulate Matter Exposure Alters Pulmonary Microbiota Composition and Aggravates Pneumococcus-Induced Lung Pathogenesis.

ABSTRACT: Exposure to fine particulate matter (PM) with aerodynamic diameter ≤2.5 μm (PM_{2. 5}) is closely correlated with respiratory diseases. Microbiota plays a key role in maintaining body homeostasis including regulation of host immune status and metabolism. As reported recently, PM_{2. 5} exposure causes microbiota dysbiosis and thus promotes disease progression. However, whether PM_{2. 5} alters pulmonary microbiota distribution and aggravates bacteria-induced pathogenesis remains unknown. In this study, we used mouse experimental models of PM_{2. 5} exposure combined with Streptococcus pneumonia infection. We characterized the airway microbiota of bronchoalveolar lavage fluid (BALF) by sequencing the 16S rRNA

SUBMITTER: Chen YW 

PROVIDER: S-EPMC7649221 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature