White Matter Hyperintensity Burden Is Associated With Hippocampal Subfield Volume in Stroke.

ABSTRACT: White matter hyperintensities of presumed vascular origin (WMH) are a prevalent form of cerebral small-vessel disease and an important risk factor for post-stroke cognitive dysfunction. Despite this prevalence, it is not well understood how WMH contributes to post-stroke cognitive dysfunction. Preliminary findings suggest that increasing WMH volume is associated with total hippocampal volume in chronic stroke patients. The hippocampus, however, is a complex structure with distinct subfields that have varying roles in the function of the hippocampal circuitry and unique anatomical projections to different brain regions. For these reasons, an investigation into the relationship between WMH and hippocampal subfield volume may further delineate how WMH predispose to post-stroke cognitive dysfu

SUBMITTER: Etherton MR 

PROVIDER: S-EPMC7649326 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature