Advances in RNA 3D Structure Modeling Using Experimental Data.

ABSTRACT: RNA is a unique bio-macromolecule that can both record genetic information and perform biological functions in a variety of molecular processes, including transcription, splicing, translation, and even regulating protein function. RNAs adopt specific three-dimensional conformations to enable their functions. Experimental determination of high-resolution RNA structures using x-ray crystallography is both laborious and demands expertise, thus, hindering our comprehension of RNA structural biology. The computational modeling of RNA structure was a milestone in the birth of bioinformatics. Although computational modeling has been greatly improved over the last decade showing many successful cases, the accuracy of such computational modeling is not only length-dependent but also varies accordin

SUBMITTER: Li B 

PROVIDER: S-EPMC7649352 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature