Impact of switching to a heat-not-burn tobacco product on CYP1A2 activity.

ABSTRACT:

Background

Cigarette smoking induces cytochrome P450 1A2 (CYP1A2) expression and activity, while smoking cessation normalizes the levels of this enzyme. The aim of this publication is to summarize the data on CYP1A2 gene expression and activity in preclinical and clinical studies on the Tobacco Heating System (THS), currently marketed as IQOS® with HEETs®, and to summarize the potential effects on CYP1A2 to be expected upon switching to reduced-risk products (RRPs).

Methods

We summarized PMI's preclinical and clinical data on the effects of switching from cigarette smoking to THS.

Results

Data from four preclinical mouse and rat studies showed that, upon either cessation of cigarette smoke exposure or switching to THS exposure, the upregulation of CYP1A2

SUBMITTER: van der Plas A 

PROVIDER: S-EPMC7649435 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature