Developing immune-regulatory materials using immobilized monosaccharides with immune-instructive properties.

ABSTRACT: New strategies for immune modulation have shown real promise in regenerative medicine as well as the fight against autoimmune diseases, allergies, and cancer. Dendritic cells (DCs) are gatekeepers of the immune system and their ability in shaping the adaptive immune responses makes DCs ideal targets for immune modulation. Carbohydrates are abundant in different biological systems and are known to modulate DC phenotype and function. However, how simple monosaccharides instruct DC function is less well understood. In this study, we used a combinatorial array of immobilized monosaccharides to investigate how they modulate DC phenotype and function and crucially the impact of such changes on downstream adaptive immune responses. Our data show that a selection of monosaccharides significantly s

SUBMITTER: Alobaid MA 

PROVIDER: S-EPMC7649522 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature