Bioinformatics Analysis of Differentially Expressed Genes and miRNAs in Low-Grade Gliomas.

ABSTRACT: Low-grade glioma is the most common type of primary intracranial tumor. In the last 3 years, new observations of molecular precursors in adults with gliomas have led to a modification in the histopathologic classification of these brain tumors. Among the biomarkers that have been highlighted, we have the micro RNAs (miRNAs) which play a crucial role in the regulation of gene expression and the long noncoding RNAs (lncRNAs) controlling various cellular and metabolic pathways. In our study, large-scale data on sequenced RNA and miRNAs from 516 patients were obtained from the Cancer Genome Atlas database by the TCGAbiolinks package. We identified the differential expression of miRNAs and genes using the Limma package and then we used the ClusterProfiler package for annotations of the biologic

SUBMITTER: Bendahou MA 

PROVIDER: S-EPMC7649870 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature