Long-lived tumor-associated macrophages in glioma.

ABSTRACT:

Background

The tumor microenvironment plays a major tumor-supportive role in glioma. In particular, tumor-associated macrophages (TAMs), which can make up to one-third of the tumor mass, actively support tumor growth, invasion, and angiogenesis. Predominantly alternatively activated (M2-polarized) TAMs are found in late-stage glioma in both human and mouse tumors, as well as in relapse samples from patients. However, whether tumor-educated M2 TAMs can actively contribute to the emergence and growth of relapse is currently debated.

Methods

To investigate whether tumor-educated stromal cells remaining in the brain after surgical removal of the primary tumor can be long-lived and retain their tumor-supporting function, we developed a transplantation mouse model and performed li

SUBMITTER: Georgieva PB 

PROVIDER: S-EPMC7649962 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature