Conditioned pain modulation in drug-naive patients with de novo Parkinson's disease.

ABSTRACT:

Background

Pain is highly prevalent in patients with Parkinson's disease (PD), but underlying pathophysiological mechanisms are largely unclear. In many chronic pain syndromes deficits in endogenous pain inhibition have been detected that can be assessed using conditioned pain modulation paradigms. Previous studies employing this approach in medicated PD patients did not find abnormal pain inhibition. However, these results might have been confounded by residual dopaminergic medication.

Methods

An established conditioned pain modulation paradigm was used in 17 drug-naïve de novo PD patients and 17 healthy age and gender-matched controls. We tested i) whether conditioned pain modulation responses differed between the patient and control group and ii) whether pain inhibition d

SUBMITTER: Grashorn W 

PROVIDER: S-EPMC7650066 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature