Skin pigmentation polymorphisms associated with increased risk of melanoma in a case-control sample from southern Brazil.

ABSTRACT:

Background

Melanoma is the most aggressive type of skin cancer and is associated with environmental and genetic risk factors. It originates in melanocytes, the pigment-producing cells. Single nucleotide polymorphisms (SNPs) in pigmentation genes have been described in melanoma risk modulation, but knowledge in the field is still limited.

Methods

In a case-control approach (107 cases and 119 controls), we investigated the effect of four pigmentation gene SNPs (TYR rs1126809, HERC2 rs1129038, SLC24A5 rs1426654, and SLC45A2 rs16891982) on melanoma risk in individuals from southern Brazil using a multivariate logistic regression model and multifactor dimensionality reduction (MDR) analysis.

Results

Two SNPs were associated with an increased risk of melanoma in a dominant

SUBMITTER: Reis LB 

PROVIDER: S-EPMC7650158 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature