Effects of thiamine on vasopressor requirements in patients with septic shock: a prospective randomized controlled trial.

ABSTRACT:

Background

Thiamine, an essential vitamin for aerobic metabolism and glutathione cycling, may decrease the effects of critical illnesses. The objective of this study was to determine whether intravenous thiamine administration can reduce vasopressor requirements in patients with septic shock.

Methods

This study was a prospective randomized double-blind placebo-controlled trial. We included adult patients with septic shock who required a vasopressor within 1-24 h after admission between March 2018 and January 2019 at a tertiary hospital in Thailand. Patients were divided into two groups: those who received 200 mg thiamine or those receiving a placebo every 12 h for 7 days or until hospital discharge. The primary outcome was the number of vasopressor-free days over 7 days. The

SUBMITTER: Petsakul S 

PROVIDER: S-EPMC7650202 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature