Genetic polymorphism and natural selection of circumsporozoite protein in Myanmar Plasmodium vivax.

ABSTRACT:

Background

Circumsporozoite surface protein (CSP) of malaria parasites has been recognized as one of the leading vaccine candidates. Clinical trials of vaccines for vivax malaria incorporating Plasmodium vivax CSP (PvCSP) have demonstrated their effectiveness in preventing malaria, at least in part. However, genetic diversity of pvcsp in the natural population remains a major concern.

Methods

A total of 171 blood samples collected from patients infected with Plasmodium vivax in Myanmar were analysed in this study. The pvcsp was amplified by polymerase chain reaction, followed by cloning and sequencing. Polymorphic characteristics and natural selection of pvcsp population in Myanmar were analysed using DNASTAR, MEGA6 and DnaSP programs. The polymorphic pattern and natural sel

SUBMITTER: Vo TC 

PROVIDER: S-EPMC7650223 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature